Author

Roberto Villaseñor

F. Hoffmann-La Roche AGORCID 0000-0002-0244-1091Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alex OdermattiD· 2 shared Angélique Augustin· 2 shared Chiara Zanini· 2 shared Christelle Zundel· 2 shared Claire Simonneau· 2 shared Filiz Sila RizalariD· 2 shared Luisa Bell· 2 shared Nadine Stokar‐RegenscheitiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Alex OdermattORCID

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Author profile →

4 papers

Recent·Most cited

Integrin-dependent trafficking of CD98hc reduces endocytic noise to maintain metabolic homeostasis

Filiz Sila Rizalar, Hans Peter Grimm, Angélique Augustin, Jose Luis Garcia-Cordero, Roberto Villaseñor

This study identifies a role for β1-integrin in regulating CD98hc trafficking to reduce endocytic noise and maintain amino acid homeostasis.

bioRxiv · Jul 27, 2026 · PreprintCell Biology

ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells

Luisa Bell, Shane Clerkin, Filiz Sila Rizalar, A. Rizkallah, Nadine Stokar‐Regenscheit, Xandor M. Spijkers, Nienke R. Wevers, Claire Simonneau, Angélique Augustin, Barbara Höllbacher, Lia D’Abate, Joanna Ficek, Kim Schneider, Désirée von Tell, Thomas L. Maurissen, , Roberto Villaseñor

The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.

Stem Cell Reports · Aug 21, 2025Peer-reviewedCell Biology

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity

Liza Malong, Jessica Roskosch, Carolina Hager, Jean‐Philippe Fortin, Roland Schmucki, Marinella G. Callow, Christian Weile, Valentina Romeo, Christoph Patsch, Scott E. Martin, Mike Costa, Zora D. Modrusan, Roberto Villaseñor, Erich Koller, Benjamin Haley, , Filip Roudnicky

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

Nature Communications · Jun 30, 2025Peer-reviewedCell Biology

Advanced Tissue Technologies of Blood-Brain Barrier Organoids as High Throughput Toxicity Readouts in Drug Development

Luisa Bell, Claire Simonneau, Chiara Zanini, Elena Kassianidou, Christelle Zundel, Rachel Neff, Bernd Steinhuber, Marco Tecilla, Alex Odermatt, Roberto Villaseñor, Nadine Stokar‐Regenscheit

Paraffin histology, multiplex immunofluorescence and MALDI imaging work on blood-brain barrier organoids; an AI apoptosis detector on hematoxylin-eosin slides (F1 0.817 vs pathologists) tracked staurosporine dose responses.

Heliyon · Dec 2, 2024Peer-reviewedPathology✦ In-depth digest