Cole A. Harrington

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study examines how aging affects oligodendrocyte progenitor cell (OPC) responses to inflammatory demyelination in a mouse model of multiple sclerosis, finding that both young and aged OPCs can differentiate into mature oligodendrocytes.

PEDIA-BRAIN provides a single nuclei multiomic resource of the human pons across development, revealing oligodendrocyte maturation trajectories and disease-related perturbations in DMG and MS.

This study presents lineage tracing results from 18 myeloid-specific fate-mapping models in mouse peripheral blood and synovial tissue, validating synovial macrophage identification through flow cytometry and CITE-seq.