Author

Xiaojing Deng

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Michael D. KornbergiD· 3 shared Jingwen HuiD· 2 shared Judy J. LeeiD· 2 shared Matthew D. SmithiD· 2 shared Paul M. KimiD· 2 shared Payam Mohammad GharibaniiD· 2 shared Peter A. CalabresiiD· 2 shared Shruthi ShanmukhaiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Michael D. KornbergORCID

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3 papers

Recent·Most cited

Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination

Judy J. Lee, Matthew D. Smith, Xiaojing Deng, Jingwen Hu, Andrew Love, Jerry S Jing, Payam Mohammad Gharibani, Pragney Deme, Abdulshakour Mohammadnia, Qiao‐Ling Cui, Daryan Chitsaz, Asmita Dhukhwa, Jaime Gonzalez Cardona, Kathryn C. Fitzgerald, Colleen T. Harrington, , Michael D. Kornberg

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

bioRxiv · Aug 15, 2026 · PreprintNeuroscience

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

Wesley H. Godfrey, Judy J. Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandrashekar R. Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D. Kornberg

This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.

eLife · Jan 30, 2025Peer-reviewedImmunology

PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination

Payam Mohammad Gharibani, Efrat Abramson, Shruthi Shanmukha, Matthew D. Smith, Wesley H. Godfrey, Judy J. Lee, Jingwen Hu, Maryna Baydyuk, Marie‐France Dorion, Xiaojing Deng, Yu Guo, Soonmyung A. Hwang, Jeffrey K. Huang, Peter A. Calabresi, Michael D. Kornberg, Paul M. Kim

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.

bioRxiv · Aug 28, 2023 · PreprintNeuroscience