Robin Leslie Owen

Use of photocaged molecular oxygen for time-resolved serial X-ray crystallography

This paper uses photocaged molecular oxygen to trigger oxygen binding in myoglobin crystals and captures structural changes using time-resolved serial X-ray crystallography.

Drop on fixed target reaction initiation approach for serial and time resolved crystallography

This paper describes a drop on fixed target method for time-resolved serial crystallography, tested with enzymes to improve measurement consistency across facilities.

Integrated structural dynamics uncover new modes of B12 photoreceptor activation

The paper describes the photoactivation mechanism of the B12 photoreceptor CarH using structural and spectroscopic methods, revealing unique intermediates that drive tetramer dissociation.

Time-resolved ligand dynamics revealed in a β-lactamase using room-temperature serial crystallography

This study uses room-temperature serial crystallography to observe time-dependent ligand dynamics of the β-lactamase CTX-M-15 with avibactam, revealing conformational changes critical for inhibitor reformation.

Double crossed? Structural and computational studies of an unusual crosslinked heme in Methylococcus capsulatus cytochrome P460

This study identifies a double crosslink between lysine and heme in Methylococcus capsulatus cytochrome P460 using structural biology and QM/MM simulations.

xia2.multiplex: a multi-crystal data analysis pipeline

xia2.multiplex merges multi-crystal data sets in macromolecular crystallography to improve data quality and facilitate analysis.