Insights from aquaporin structures into drug-resistant sleeping sickness
Modestas Matusevicius, Robin Adam Corey, Marcos Gragera, Keitaro Yamashita, Teresa Sprenger, Marzuq A. Ungogo, James N. Blaza, Pablo Castro‐Hartmann, Dimitri Y. Chirgadze, Sundeep Chaitanya Vedithi, Pavel Afanasyev, Roberto Melero, Rangana Warshamanage, Anastasiia Gusach, J.M. Carazo, , Simone N. Weyand
This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.
eLife · Dec 31, 2025Peer-reviewedMolecular Biology