Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response
Lindsey Lammlin, Lucas M. Junginger, Alexander J. Knights, Michael D. Newton, Henry Dai, Carlisle R. DeJulius, Aanya Mohan, Isabelle J. Smith, Scarlet C. Howser, Gurjit S. Mandair, Sunghun Cheong, Paul F Lais, Sofia Gonzalez-Nolde, Andrea I. Alford, Kurt David Hankenson, Tristan Maerz
This study shows that TSP2 deficiency leads to increased joint inflammation and worsened osteoarthritis after injury, suggesting TSP2's role in joint homeostasis.
bioRxiv · Jun 22, 2026 · PreprintPhysiology