Author

Alfred W. Bronkhorst

Institute of Molecular BiologyORCID 0000-0001-6402-574XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Organism:multiple species· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

René F. KettingiD· 3 shared António Miguel de Jesus DominguesiD· 2 shared Falk ButteriD· 2 shared Alexander van OudenaardeniD· 1 shared Chop Yan LeeiD· 1 shared Dominic GrüniD· 1 shared Elke F. RooversiD· 1 shared Emil Karaulanov· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMolecular Biology

René F. KettingORCID

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3 papers

Recent·Most cited

Molecular BiologyNaturePeer-reviewedSep 27, 2023

piRNA processing by a trimeric Schlafen-domain nuclease

Nadezda Podvalnaya, Alfred W. Bronkhorst, Raffael Lichtenberger…·René F. Ketting

The paper identifies PUCH, a trimeric Schlafen-domain nuclease that initiates piRNA processing in C. elegans by cleaving 5-end piRNA precursors, revealing a novel RNA endonuclease mechanism.

47 citationstop 2%

C. elegansexperimental assay

Molecular BiologybioRxivPreprintMar 23, 2023

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

Alfred W. Bronkhorst, Chop Yan Lee, Martin M. Möckel…·René F. Ketting

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.

2 citations

multiple speciesstatistical model

Molecular BiologyDevelopmental CellPeer-reviewedAug 1, 2018

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

Elke F. Roovers, Lucas J. T. Kaaij, Stefan Redl…·René F. Ketting

This study identifies Tdrd6a as a regulator of Buc protein aggregation, which is essential for forming subcellular compartments that drive germ cell specification in zebrafish.

88 citations

zebrafishprotein sequence