Author

Nadezda Podvalnaya

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

René F. KettingiD· 3 shared Emily NischwitziD· 2 shared Falk ButteriD· 2 shared Sebastian FalkiD· 2 shared Adrian Söderholm· 1 shared Alfred W. BronkhorstiD· 1 shared Anke BuschiD· 1 shared Ann‐Sophie SeistrupiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

René F. KettingORCID

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3 papers

Recent·Most cited

SLBP-independent control of maternal histone mRNA

Joana Pereirinha, Martin Brehm, Shamitha Govind, Anke Busch, Nadezda Podvalnaya, Ann‐Sophie Seistrup, Kamila Delaney, Florian A Steiner, Julian König, Sebastian Falk, René F. Ketting

The paper identifies an SLBP-independent mechanism for maintaining maternal histone mRNA stability in C. elegans oogenesis, mediated by the PETISCO complex and TOST-1.

bioRxiv · Jan 6, 2026 · PreprintMolecular Biology

ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA

Adrian Söderholm, Milica Vunjak, Melanie de Almeida, Niko P. Popitsch, Nadezda Podvalnaya, Pablo Araguas-Rodriguez, Sara Scinicariello, Emily Nischwitz, Falk Butter, René F. Ketting, Stefan Ludwig Ameres, Michaela Müller-McNicoll, Johannes A. Zuber, Gijs A. Versteeg

The paper identifies ERH and associated factors as post-transcriptional regulators of JAK2 mRNA maturation, essential for IFNγ signaling and innate immunity.

Nucleic Acids Research · Jun 6, 2025Peer-reviewedCell Biology

piRNA processing by a trimeric Schlafen-domain nuclease

Nadezda Podvalnaya, Alfred W. Bronkhorst, Raffael Lichtenberger, Svenja Hellmann, Emily Nischwitz, Torben Falk, Emil Karaulanov, Falk Butter, Sebastian Falk, René F. Ketting

The paper identifies PUCH, a trimeric Schlafen-domain nuclease that initiates piRNA processing in C. elegans by cleaving 5-end piRNA precursors, revealing a novel RNA endonuclease mechanism.

Nature · Sep 27, 2023Peer-reviewedMolecular Biology