António Miguel de Jesus Domingues

Batch Effect Correction in a Functional Colorectal Cancer Organoid Clinical Correlation Study

The paper describes methods to detect, characterize, and correct batch effects in a colorectal cancer organoid drug-response study to improve data reproducibility and interpretation.

miR214 regulates sex determination through gsdf in zebrafish

The paper identifies miR214 and dnm3os as regulators of sex determination in zebrafish, showing miR214 promotes female development through gsdf and dnm3os has a maternal effect on sex determination.

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.

Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish

The paper investigates post-migratory zebrafish primordial germ cells, finding delayed gene activation, nuclear gyration, and piRNA pathway activation without nuclear Piwi proteins.

The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo

The paper identifies PID-2 and related proteins as essential for establishing and maintaining RNAe in C. elegans embryos through interactions with eTudor domain proteins and proteolysis.

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways

The paper investigates maternal and zygotic gene regulatory effects of endogenous RNAi pathways in C. elegans, revealing how sRNA-Argonaute complexes influence gene silencing across generations.

RppH can faithfully replace TAP to allow cloning of 5’-triphosphate carrying small RNAs

The paper shows that RppH can replace TAP for small RNA library preparation, preserving 5’-triphosphate groups and maintaining comparable results.

PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability

The paper identifies PETISCO as a novel protein complex essential for 21U RNA biogenesis and embryonic viability in C. elegans, revealing its distinct roles from PID-1.

Tdrd6a regulates the aggregation of Buc into functional subcellular compartments that drive germ cell specification

This study identifies Tdrd6a as a regulator of Buc protein aggregation, which is essential for forming subcellular compartments that drive germ cell specification in zebrafish.