Richard R. Meehan

This study develops and evaluates two cytokine-based protocols to generate functional hepatocyte-like cells from mouse embryonic stem cells, with the advanced cocktail producing more mature cells.

The paper shows that PRC1 and PRC2 are independently recruited to hypomethylated pericentromeric heterochromatin in mESCs without requiring specific mediators.

This study identifies and corrects a major source of error in DIP-seq data, revealing new biological insights and proposing methodological improvements.

This study compares gene expression changes in rodent models of methyl donor deficiency with human NAFLD, finding limited similarity but shared inflammatory and fibrotic pathways.

This study shows that TEX19.1 restricts L1 retrotransposon mobilisation in mouse embryonic stem cells by promoting the degradation of L1-ORF1p.