Cancer BiologybioRxivPreprint
TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia
Alexandra Schurer, Humaira Ilyas, Maxim I. Maron…·David Shechter
This study identifies TTLL4 as a therapeutic target in NPM1-mutated AML by showing its role in stabilizing NPM1c and promoting differentiation block, with a small molecule inhibitor demonstrating efficacy.