Cancer BiologybioRxivPreprint
Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis
Tuo Li, Qinglin Yang, Kailiang Qiao…·Zhijian J. Chen
This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.