Author

Kailiang Qiao

Children's Medical CenterORCID 0000-0002-6097-0338Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

Huocong HuangiD· 3 shared Sihan WuiD· 3 shared Collin GilbreathiD· 2 shared Jun Yi Stanley LimiD· 2 shared Qing‐Lin YangiD· 2 shared Tuo LiiD· 2 shared Xiaohui SuniD· 2 shared Xiongfeng CheniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Huocong HuangORCID

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4 papers

Recent·Most cited

Cis and Trans Regulatory Mechanisms of ecDNA Segregation

Yipeng Xie, Jun Yi Stanley Lim, Wenyue Liu, Collin Gilbreath, Xiaohui Sun, Kailiang Qiao, Yoon Jung Kim, Sihan Wu

This study identifies cis and trans regulatory mechanisms governing ecDNA segregation, showing H3K27ac and bromodomain proteins mediate interactions, while inactive Pol II facilitates attachment.

Nature Cell Biology · Jun 24, 2026Peer-reviewedCancer Biology

Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis

Tuo Li, Qinglin Yang, Kailiang Qiao, Anli Zhang, Chenglong Sun, Huocong Huang, Paul S. Mischel, Sihan Wu, Zhijian J. Chen

This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.

bioRxiv · Jan 1, 2026 · PreprintCancer Biology

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

Kailiang Qiao, Qing‐Lin Yang, Tuo Li, Xiongfeng Chen, Zeynep Yazgan, Yoon Jung Kim, Collin Gilbreath, Jun Yi Stanley Lim, Yipeng Xie, Xiaohui Sun, Yang Liu, Yiyue Jia, Zhijian J. Chen, Huocong Huang, Sihan Wu

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.

bioRxiv · Nov 15, 2025 · PreprintCancer Biology

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Xiongfeng Chen, Zhuan Zhou, Luyu Xie, Kailiang Qiao, Yiyue Jia, Si Liu, Zeynep Yazgan, Francesca Rossi, Yang Liu, Bo Zhang, Patricio Marcelo Polanco, Herbert J. Zeh, Alex C. Kim, Huocong Huang

Pan-cancer single-cell and spatial profiling resolves two antigen-presenting CAF lineages: tumor-adjacent mesothelial-like apCAFs and tertiary lymphoid structure-associated fibrocyte-like apCAFs, both secreting pro-tumorigenic SPP1.

Cancer Cell · Sep 25, 2025Peer-reviewedCancer Biology✦ In-depth digest