Ingo Willuhn

This study investigates how dopamine in the ventromedial striatum integrates motivated action and reward proximity in rats using a Go/No-go task.

The study shows that the direct and indirect pathways of the basal ganglia have opposing effects on perceptual decisions and cortical activity in mice during visual detection and working memory tasks.

This study investigates behavioral flexibility in OCD using SAPAP3 knockout mice, finding that enhancing reward-cue salience improves reversal learning by restoring sign-tracking behavior.

This study compares Pavlovian and operant conditioning in rats to show that operant action anticipation induces sustained dopamine release in the nucleus accumbens, distinct from reward prediction error signals.

The paper shows that cocaine seeking and taking are oppositely regulated by dopamine in rats, with cue-evoked dopamine changes linked to relapse and escalated consumption.

This study investigates how deep-brain stimulation (DBS) affects neuronal activity and behavior in a mouse model of compulsive grooming, finding dose-dependent effects and specific involvement of the medial orbitofrontal cortex.

This paper introduces an automated method to quantify burying bouts and activity characteristics in the marble burying test using machine learning, revealing differences in behavior across mouse models of neurodevelopmental disorders.

SpecSeg segments neurons and neurites in chronic calcium imaging data using cross-spectral power analysis for ROI detection and registration.

NINscope is an open-source miniscope that enables multi-region neural activity recording and optogenetic stimulation in unrestrained mice, revealing functional connectivity and behavioral correlations.

This study investigates how hyperdopaminergic states affect decision-making in rats by examining the role of VTA projections to the nucleus accumbens and prefrontal cortex.