Tycho M. Hoogland

This study investigates how sleep affects cerebellar processing in adult mice by examining correlations between muscle twitches, EEG, and climbing fiber activity during different sleep stages.

The paper investigates how inhibitory and excitatory inputs to olivary neurons interact to generate spiking patterns, showing that timing of inputs affects phase and gain of the output.

The paper investigates how climbing fiber activity in the cerebellum adapts to the saliency of sensory inputs and correlates with action readiness in mice during a go/no-go task.

NINscope is an open-source miniscope that enables multi-region neural activity recording and optogenetic stimulation in unrestrained mice, revealing functional connectivity and behavioral correlations.

The paper investigates how inferior olive neurons respond to different sensory inputs and shows their firing is influenced by recent activity history rather than stimulus strength.

This study shows that increased simple spike activity in Purkinje cells, facilitated by long-term potentiation at parallel fiber synapses, contributes to whisker reflex adaptation in mice.