Bastijn J.G. van den Boom

SPOUT: An open-source hardware and software platform to study decision making while manipulating and recording from neural activity

SPOUT is an open-source platform for studying decision-making in mice by integrating neural recording and manipulation with behavioral tasks.

Striatal activity maintains a short-term action-outcome memory to guide future choice

This study shows that striatal activity encodes short-term action-outcome memories to guide future decisions in mice.

Rescuing behavioral flexibility in a mouse model for OCD by enhancing reward-cue salience

This study investigates behavioral flexibility in OCD using SAPAP3 knockout mice, finding that enhancing reward-cue salience improves reversal learning by restoring sign-tracking behavior.

Unraveling the therapeutic mechanism of deep-brain stimulation

This study investigates how deep-brain stimulation (DBS) affects neuronal activity and behavior in a mouse model of compulsive grooming, finding dose-dependent effects and specific involvement of the medial orbitofrontal cortex.

Nucleus-accumbens dopamine tracks aversive-stimulus duration and prediction but not value or prediction error

SpecSeg: cross spectral power-based segmentation of neurons and neurites in chronic calcium imaging datasets

SpecSeg segments neurons and neurites in chronic calcium imaging data using cross-spectral power analysis for ROI detection and registration.

NINscope: a versatile miniscope for multi-region circuit investigations

NINscope is an open-source miniscope that enables multi-region neural activity recording and optogenetic stimulation in unrestrained mice, revealing functional connectivity and behavioral correlations.