Johanna Van Den Daele

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

The paper develops an imaging assay with CNNs to accurately identify cell types in dense mixed neural cultures, outperforming time-based classification and enabling quality control of iPSC-derived models.

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.