Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Cole S. Sitron, Victoria A. Trinkaus, Ana Galesic, Maximilian Garhammer, Patricia Yuste‐Checa, Ulrich Dransfeld, Dennis Feigenbutz, Jiuchun Zhang, Larysa Ivashko, Irina Dudanova, J. Wade Harper, F. Ulrich Hartl
This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.
Molecular Cell · Sep 1, 2025Peer-reviewedBiochemistry