Author

Alexandra Grote

Broad InstituteORCID 0000-0002-1887-4190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Genomics· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Organism:human· 3 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ashlee M. EarliD· 3 shared Abigail L. MansoniD· 2 shared Adam B. GeberiD· 2 shared Denis VoroniniD· 2 shared Elodie GhediniD· 2 shared Jonathan LivnyiD· 2 shared Abigail E. Rose· 1 shared Alexandra C. Schrimpe‐RutledgeiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Ashlee M. EarlORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An Anaerobic Pathogen Rewires Host Metabolism to Fuel Oxidative Growth in the Inflamed Gut

Luisella Spiga, Ryan T. Fansler, Yifan Wu, Alexandra Grote, Madison Langford-Butler, Asia K. Miller, M J Neal, Owen F. Hale, Deepanshu Singla, M. Wade Calcutt, Abigail E. Rose, Madeline M. Bresson, Alexandra C. Schrimpe‐Rutledge, Brittany M. Berdy, Simona G. Codreanu, , Wenhan Zhu

This study shows how ETBF reprograms host metabolism to create an oxidative niche that supports its growth in the inflamed gut.

Cell · Apr 30, 2026Peer-reviewedMicrobiology

Persistent Salmonella infections in humans are associated with mutations in the BarA/SirA regulatory pathway

Alexandra Grote, Bar Piscon, Abigail L. Manson, Boaz Adani, Helit Cohen, Jonathan Livny, Ashlee M. Earl, Ohad Gal‐Mor

The paper identifies mutations in the BarA/SirA regulatory pathway in persistent Salmonella infections, showing they reduce virulence and inflammation.

Cell Host & Microbe · Jan 1, 2024Peer-reviewedGenomics

StrainGE: A toolkit to track and characterize low-abundance strains in complex microbial communities

Lucas R. van Dijk, Bruce J. Walker, Timothy J. Straub, Colin J. Worby, Alexandra Grote, Henry L. Schreiber, Christine Anyansi, Amy J. Pickering, Scott J. Hultgren, Abigail L. Manson, Thomas Abeel, Ashlee M. Earl

StrainGE identifies low-abundance microbial strains from metagenomic data with higher sensitivity and resolution than existing tools.

Genome biology · Mar 7, 2022Peer-reviewedBioinformatics

Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

David M. Curran, Alexandra Grote, Nirvana Nursimulu, Adam B. Geber, Denis Voronin, Drew R. Jones, Elodie Ghedin, John Parkinson

The paper models the metabolic interactions between a parasitic worm and its bacterial endosymbiont to identify potential drug targets.

eLife · Aug 10, 2020Peer-reviewedSystems Biology

Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting

Alexandra Grote, Yichao Li, Canhui Liu, Denis Voronin, Adam B. Geber, Sara Lustigman, Thomas Raymond Unnasch, Lonnie R. Welch, Elodie Ghedin

The paper develops a motif prediction pipeline to identify regulatory motifs in Brugia malayi, focusing on those involved in the L3-L4 molt stage.

PLoS neglected tropical diseases · Jun 23, 2020Peer-reviewedBioinformatics