Anthony B. Firulli

The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

The paper evaluates HAND2 gene regulatory networks in endocardial cells using single-cell transcriptomics to identify HAND2-dependent enhancers and their impact on cardiac morphogenesis.

This study shows that Gata3 disruption in mouse embryos causes facial abnormalities due to impaired separation of mandibular and maxillary domains during development.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.