Author

Rajani M. George

Indiana University School of MedicineORCID 0000-0002-9153-5523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Andrew R FieldiD· 1 shared Anthony B. FirulliiD· 1 shared Beth A. FirulliiD· 1 shared Brandon J. MannioniD· 1 shared Charlie Harper· 1 shared Douglas B. RuschiD· 1 shared Jaclyn Essig· 1 shared Jordane DimidschsteiniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Andrew R FieldORCID

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2 papers

Recent·Most cited

PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome

Perry W.E. Spratt, Nicholas F. Trojanowski, Rajani M. George, Olivia Stevenson, Tessa Nottonson, Joshua Reiser, Lucia Capano, Andrew R Field, Jaclyn Essig, Michael Faundo, Yan Hung, Navneet Kaur Matharu, Charlie Harper, Orrin Devinsky, Jordane Dimidschstein, Kathryn C. Allaway

This study uses CRISPR activation to upregulate SCN1A in PV interneurons, improving survival and reducing seizures in Dravet syndrome models.

bioRxiv · Jul 14, 2026 · PreprintNeuroscience

Single cell evaluation of endocardial HAND2 gene regulatory networks reveals critical HAND2 dependent pathways impacting cardiac morphogenesis.

Rajani M. George, Beth A. Firulli, Ram Podicheti, Douglas B. Rusch, Brandon J. Mannion, Len A. Pennacchio, Marco Osterwalder, Anthony B. Firulli

The paper evaluates HAND2 gene regulatory networks in endocardial cells using single-cell transcriptomics to identify HAND2-dependent enhancers and their impact on cardiac morphogenesis.

Development · Jan 9, 2023Peer-reviewedDevelopmental Biology