Lucrezia Criscuolo

STEP-PTM enables integrated quantitative analysis of proteome, metabolome, and multiple PTM classes from single biological samples using a modular TMT-multiplexed workflow.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.