Marie Sejberg Øhlenschlæger

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

Modeling Synaptic Maturation from Growth Cone to Synapse in Human Organoids

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profiles

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.