Gaetano D’Amato

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

The paper shows that coronary endothelial cells in mouse and human hearts initially show lineage-specific transcriptional differences but later become influenced by location, with adult cells becoming more homogeneous.

This study shows that overexpressing Dach1 in endothelial cells extends coronary arteries and improves heart function after myocardial infarction in mice.

This study shows that deleting NOTCH-RBPJ in the myocardium does not impair heart development or function, but deleting it in both myocardial and endocardial progenitors causes cardiac defects.