Tatyana Lev

Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

A spatially resolved single cell genomic atlas of the adult human breast

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.