Matthew K. Kirchner

This study shows that Magel2 deficiency in a mouse model of Prader-Willi syndrome causes microglial structural changes and increased synaptic engulfment, altering neuron-microglia interactions and hypothalamic circuit function.

This study identifies how somatodendritic vasopressin release converts intrinsic neuronal excitability into spatially organized population-level feedback in VP neurons.

This study identifies vagal afferents expressing the oxytocin receptor that mediate mechanosensation of the heart and gut, leading to hypometabolism and vigilance in mice.

This study shows that Angiotensin-II increases microglia-vascular interactions in rat heart failure models, leading to neuroinflammation that can be mitigated by blocking AngII receptors.

This study investigates changes in the oxytocinergic circuit in the central amygdala of rats with chronic heart failure, finding impaired OT release and receptor function.

The paper identifies a vasopressin circuit in mice that modulates sex-specific social interest and anxiety-like behavior through projections from the BNST to the lateral septum.

The paper identifies Lmx1a as a master regulator that coordinates the formation and function of the cortical hem, a signaling center critical for hippocampus development.

This study examines the oxytocin system and OTR-expressing astrocytes in a mouse model of PWS, finding reduced oxytocin cells and OTR-expressing astrocytes in specific brain regions with sex-specific differences.

This study shows that oxytocin acts on astrocytes in the central amygdala to promote a positive emotional state, challenging the notion that oxytocin only affects neurons.