Henning Fröhlich

Magel2 deficiency drives microglial synaptic engulfment and alters neuron-microglia interactions in Prader-Willi syndrome

This study shows that Magel2 deficiency in a mouse model of Prader-Willi syndrome causes microglial structural changes and increased synaptic engulfment, altering neuron-microglia interactions and hypothalamic circuit function.

FOXP1 differentially regulates the development of murine vasopressin and oxytocin magnocellular neurons

The paper identifies FOXP1 as a key regulator of oxytocin neuron differentiation and shows its role in reducing AVP and OXT neuron abundance in knockout mice.

Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome

This study examines the oxytocin system and OTR-expressing astrocytes in a mouse model of PWS, finding reduced oxytocin cells and OTR-expressing astrocytes in specific brain regions with sex-specific differences.

Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

This study shows that mitochondrial dysfunction and oxidative stress in Foxp1+/- mice contribute to cognitive and motor impairments in FOXP1 syndrome.