Author

Gregory N Stephanopoulos

Massachusetts Institute of TechnologyORCID 0000-0001-6909-4568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Andrew A. LaneiD· 1 shared Anush Chiappino-PepeiD· 1 shared Ayşegül Erdem· 1 shared Azeem ShardaiD· 1 shared Charles VidoudeziD· 1 shared David T. ScaddeniD· 1 shared Didier VertommeniD· 1 shared Fleur Leguay· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Andrew A. LaneORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells

Nithya Balasundaram, Ayşegül Erdem, Azeem Sharda, Veerle W. Daniëls, Phillip L. Chea, Fleur Leguay, YOUZHONG LIU, Mark A. Keibler, Charles Vidoudez, Andrew A. Lane, Didier Vertommen, Hans Casteur, Michaël R. Laurent, Sunia A. Trauger, Gregory N Stephanopoulos, , Nick van Gastel

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

bioRxiv · Mar 3, 2026 · PreprintCancer Biology

NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells

Sun Jin Moon, Anush Chiappino-Pepe, Wentao Dong, Joanne K. Kelleher, Matthew G. Vander Heiden, Gregory N Stephanopoulos, Hadley D. Sikes

The paper quantifies the relationship between compartmentalized NADPH dynamics and cancer cell growth rates using a composite index analysis and identifies key transporters involved in this relationship.

bioRxiv · Apr 27, 2024 · PreprintSystems Biology