Renan Escalante-Chong

The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.

The paper identifies GAL3 polymorphisms in yeast that explain variation in galactose utilization decisions and diauxic lag across strains.

The paper develops a freezing protocol for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells, showing that slow-cooled cryopreserved samples yield comparable results to fresh cells.

The paper shows that yeast strains prepare for nutrient depletion by inducing metabolism genes before glucose exhaustion, revealing a cost-benefit tradeoff in growth strategies.