Hiroki R. Ueda

Genome-wide epitope identification with single-amino-acid resolution via high-throughput and unbiased peptide analysis

This study introduces DECODE, a high-throughput method for identifying epitopes at single amino acid resolution, demonstrating its utility in antibody-based research and disease modeling.

Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles

The paper identifies PKA and phosphatases as regulators of sleep-wake cycles through genetic and functional studies in mice.

Boundary conditions for synaptic homeodynamics during the sleep-wake cycle

The paper uses computational models to explore synaptic dynamics during the sleep-wake cycle, finding that wake-like firing patterns decrease synaptic weights while sleep-like patterns increase them, offering a unified framework for synaptic homeodynamics.

A design principle of slow-wave sleep firing pattern with Na+ dynamics

The paper introduces a revised neuronal model incorporating Na+ dynamics to explain slow-wave sleep firing patterns and their transition mechanisms.

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

A Framework to Determine Active Connectivity within the Mouse Brain

The paper develops a framework to determine active connectivity in the mouse brain by combining experimental and computational methods to identify the most active neural networks during different times of the day.

Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβ

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.

CUBIC-Cloud: An Integrative Computational Framework Towards Community-Driven Whole-Mouse-Brain Mapping

CUBIC-Cloud is a cloud-based framework for analyzing and integrating whole mouse brain data, demonstrating applications in cell distribution, plaque quantification, neuronal activity, and connectivity mapping.

Comparison of the 3-D patterns of the parasympathetic nervous system in the lung at late developmental stages between mouse and chicken

This study compares the 3-D patterns of parasympathetic nerves in mouse and chicken lungs during late development, revealing three key similarities in nerve distribution and function.