Arndt F. Siekmann

Alk1/Endoglin dependent increases in vein endothelial cell sizes precipitate arteriovenous malformations

This study identifies Alk1/Endoglin signaling as critical for restricting vein endothelial cell sizes and preventing arteriovenous malformations in zebrafish embryos.

Temporally and regionally distinct morphogenetic processes govern zebrafish tail fin blood vessel network expansion

The paper identifies temporally and spatially distinct morphogenetic processes in zebrafish tail fin vascular development.

Distinct Vegfa isoforms control endothelial cell proliferation through PI3 kinase signalling mediated regulation of cdkn1a/p21

This study shows that Vegfa isoforms differentially regulate endothelial cell proliferation via PI3K signaling, independent of MAPK (ERK) activation in zebrafish.

DNA motif analysis of shear stress responsive endothelial enhancers reveals differential association of KLF and ETV/ETS binding sites with gained and lost enhancers

Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signaling for their development

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.