Roman Manetsch

This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.

This study evaluates two 4(1H)-quinolone compounds for their efficacy against both acute and chronic Toxoplasma gondii infection, showing potent activity against tachyzoites and bradyzoites.

This paper demonstrates that a cyclic thiosulfinate cross-linker stabilizes SOD1 variants in vivo, showing efficacy and low toxicity for treating SOD1-related ALS.

The paper reports the structural determination of 19 N. fowleri proteins, identifying potential drug targets with structural differences from human homologs.

This study identifies mitochondrial heteroplasmy as the cause of Atovaquone resistance in Plasmodium falciparum, showing pre-existing Y268S alleles in the mitochondrial genome contribute to drug resistance.