Misha Y. Zilberter

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

The paper shows that PV+ and SST+ interneurons in the DG and CA3 differentially modulate information flow to CA1 by altering coupling signatures from CA3 and entorhinal cortex.

Aβ1-42 induces brain hypometabolism, network hyperactivity, and behavioral changes via NOX2-mediated oxidative stress, suggesting a novel therapeutic target for Alzheimer's disease treatment.

This study shows that trkB signaling is critical for adult parvalbumin interneuron function and prefrontal network dynamics in mice.