Ian S. Hitchcock

A first-in-class CAR T-cell therapy targeting mutant calreticulin selectively depletes malignant stem cells in vivo and in fibrotic human organoids.

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

This study shows that platelet depletion in schistosomiasis leads to severe bleeding and reduced survival, while platelets do not directly drive macrophage activation in type 2 inflammation.