Author

Peiguo Shi

Columbia University Irving Medical CenterORCID 0000-0001-7177-8336Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Aditi Trehan· 2 shared Alexis O. AparicioiD· 2 shared Michael Robert MurphyiD· 2 shared Xuebing WuiD· 2 shared Colin H. KalickiiD· 1 shared Esther R. RotleviiD· 1 shared Feiyue YangiD· 1 shared Jianwen QueiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersGenomics

Aditi Trehan

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJan 30, 2026

Decoding the MYC locus reveals a druggable ultraconserved RNA element

Peiguo Shi, Feiyue Yang, Tala FNU…·Xuebing Wu

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

DOI 10.64898/2026.01.29.702547

humanCRISPR screen

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Molecular BiologybioRxivPreprintNov 30, 2021

RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells

Peiguo Shi, Michael Robert Murphy, Alexis O. Aparicio…·Xuebing Wu

This paper demonstrates that targeting a single marker RNA with CRISPR/RfxCas13d causes collateral transcriptome destruction, enabling inhibition of cell proliferation or suppression of cell state transition in human cells.

21 citations

humanbulk RNA-seq

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