Feiyue Yang

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

The paper identifies a pathogenetic mechanism for RPL3L-linked dilated cardiomyopathy, showing that gain-of-toxicity variants in muscle-specific ribosomes cause severe neonatal heart failure.

The paper determines the structure of a plant-virus xrRNA and shows it forms a pseudoknot that confers exoribonuclease resistance, revealing a conserved mechanism across diverse viruses.