Author

Alexis O. Aparicio

Columbia University Irving Medical CenterORCID 0000-0002-1107-2718Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Xuebing WuiD· 3 shared Aditi Trehan· 2 shared Jordan S. KesneriD· 2 shared Michael Robert MurphyiD· 2 shared Peiguo ShiiD· 2 shared Ziheng CheniD· 2 shared Colin H. KalickiiD· 1 shared Esther R. RotleviiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Xuebing WuORCID

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3 papers

Recent·Most cited

Decoding the MYC locus reveals a druggable ultraconserved RNA element

Peiguo Shi, Feiyue Yang, Tala FNU, Wesley Huang, Alexis O. Aparicio, Colin H. Kalicki, Aditi Trehan, Michael Robert Murphy, Esther R. Rotlevi, Linqing Xing, Muredach P. Reilly, Jianwen Que, Xuebing Wu

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

bioRxiv · Jan 30, 2026 · PreprintGenomics

A unified model for the surveillance of translation in diverse noncoding sequences

Jordan S. Kesner, Ziheng Chen, Alexis O. Aparicio, Xuebing Wu

The paper identifies a fail-safe mechanism for surveilling translation in noncoding regions, showing that hydrophobic C-terminal tails of noncoding-derived polypeptides are targeted by the BAG6 complex for degradation or membrane localization.

bioRxiv · Jul 20, 2022 · PreprintMolecular Biology

RNA-guided cell targeting with CRISPR/RfxCas13d collateral activity in human cells

Peiguo Shi, Michael Robert Murphy, Alexis O. Aparicio, Jordan S. Kesner, Zhou Fang, Ziheng Chen, Aditi Trehan, Xuebing Wu

This paper demonstrates that targeting a single marker RNA with CRISPR/RfxCas13d causes collateral transcriptome destruction, enabling inhibition of cell proliferation or suppression of cell state transition in human cells.

bioRxiv · Nov 30, 2021 · PreprintMolecular Biology