Xuebing Wu

CRISPRtile is a cloud-based platform that uses AI to improve drug design by predicting functional modulators with reduced error and computational cost.

The paper maps the functional fitness landscape of the MYC locus, identifies an ultraconserved RNA element critical for MYC function, and shows it can be targeted to kill MYC-addicted cancer cells.

The paper identifies a pathogenetic mechanism for RPL3L-linked dilated cardiomyopathy, showing that gain-of-toxicity variants in muscle-specific ribosomes cause severe neonatal heart failure.

The paper identifies a fail-safe mechanism for surveilling translation in noncoding regions, showing that hydrophobic C-terminal tails of noncoding-derived polypeptides are targeted by the BAG6 complex for degradation or membrane localization.

This paper demonstrates that targeting a single marker RNA with CRISPR/RfxCas13d causes collateral transcriptome destruction, enabling inhibition of cell proliferation or suppression of cell state transition in human cells.

The paper identifies a genetic pathway in C. elegans that mediates cold-warming response and promotes stress-induced phenoptosis through ZIP-10 regulation.

kpLogo detects and visualizes position-specific ultra-short motifs in biological sequences by addressing limitations of existing tools.