Decoding chromosome organization using CheC-PLS: chromosome conformation by proximity labeling and long-read sequencing
Kewei Xu, Yichen Zhang, James G. Baldwin-Brown, Thomas A. Sasani, Nitin Phadnis, Matthew P. Miller, Ofer Rog
The paper introduces CheC-PLS, a proximity-labeling technique that uses Nanopore sequencing to decode chromosome organization by identifying methylated bases along long reads, demonstrating its application in budding yeast.
Journal of genetics and genomics/Journal of Genetics and Genomics · May 17, 2026Peer-reviewedGenomics