This paper creates a human embryonic limb cell atlas using single-cell and spatial transcriptomics, identifying novel cell populations and developmental patterns.

Nature · Dec 6, 2023Peer-reviewedDevelopmental Biology

Spatially resolved multiomics of human cardiac niches

Kazumasa Kanemaru, James J. Cranley, Daniele Muraro, Antonio M. A. Miranda, Siew Yen Ho, Anna Wilbrey-Clark, J. Patrick Pett, Krzysztof Polański, Laura Richardson, Monika Litviňuková, Natsuhiko Kumasaka, Yue Qin, Zuzanna Jablonska, Claudia I. Semprich, Lukáš Mach, , Sarah Amalia Teichmann

This paper uses spatial transcriptomics and single-cell data to identify cellular niches in the human heart, revealing new insights into cardiac function and potential drug targets.

Nature · Jul 12, 2023Peer-reviewedGenomics

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

Peng He, Kyungtae Lim, Dawei Sun, J. Patrick Pett, Quitz Jeng, Krzysztof Polański, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika H. Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, , Emma L. Rawlins

The paper constructs a human fetal lung cell atlas from 5-22 post conception weeks, identifying new cell states and regulators of epithelial fates.

Cell · Dec 1, 2022Peer-reviewedDevelopmental Biology

Human skeletal muscle ageing atlas

Veronika R. Kedlian, Yaning Wang, Tianliang Liu, Xiaoping Chen, Liam Bolt, Zhuojian Shen, Eirini Sofia Fasouli, Elena Prigmore, Vitalii Kleshchevnikov, Tong Li, John E. G. Lawrence, Ni Huang, Qin Guo, Lu Yang, Krzysztof Polański, , Hongbo Zhang

This study creates a single-cell and single-nucleus transcriptomic atlas of human skeletal muscle ageing, revealing mechanisms in muscle stem cells, myofibers, and the microenvironment.

bioRxiv · May 24, 2022 · PreprintGenomics

Multi-regional characterisation of renal cell carcinoma and microenvironment at single cell resolution

Ruoyan Li, John Robert Ferdinand, Kevin W. Loudon, Georgina Bowyer, Lira Mamanova, Joana Briosa Neves, Liam Bolt, Eirini Sofia Fasouli, Andrew R. J. Lawson, Matthew D. Young, Yvette E. Hooks, Thomas R. W. Oliver, Timothy M. Butler, James N. Armitage, Tev Aho, , Thomas J. Mitchell

A multi-regional single-cell study of kidney tumours reveals clonotypic heterogeneity, immune cell exhaustion, and potential therapeutic targets through transcriptomic and exomic analysis.

bioRxiv · Nov 12, 2021 · PreprintGenomics

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Christoph Muus, Malte D. Luecken, Gökçen Eraslan, Avinash Waghray, Graham Heimberg, Lisa Sikkema, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smilie, Karthik A. Jagadeesh, Thu Elizabeth Duong, Evgenij Fiškin, Elena Torlai Triglia, Meshal Ansari, , Wenjun Yan

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.

bioRxiv · Apr 19, 2020 · PreprintBioinformatics✦ In-depth digest