Author

Pauline Johnson

University of British ColumbiaORCID 0000-0001-7367-4653Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Anjali Parthasarathy· 1 shared Calvin D. RoskelleyiD· 1 shared Earl Johan FosteriD· 1 shared Eddy Sánchez‐LeóniD· 1 shared Guanggan HuiD· 1 shared Halen Kovacs· 1 shared James W. KronstadiD· 1 shared Jen Chin C. WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Anjali Parthasarathy

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2 papers

Recent·Most cited

A genome-wide CRISPR screen reveals cancer-specific regulators of hyaluronan binding and cellular invasion

Jimmy Kim, Halen Kovacs, Anjali Parthasarathy, Shini Chen, Vignesh Krishnamoorthy, Mohammed Al‐Seragi, May Zhao, Yu‐Hsuan Huang, Pamela Austin Dean, Pauline Johnson, Calvin D. Roskelley, Simon Wisnovsky

This study uses a CRISPR screen to identify genes regulating CD44-HA binding in breast cancer, revealing RAB4A as a novel regulator of invasion and potential therapeutic target.

bioRxiv · Feb 9, 2026 · PreprintCancer Biology

Polyphosphate mobilization influences the ability of Cryptococcus neoformans to cause disease in a murine model of cryptococcosis

Kabir Bhalla, Eddy Sánchez‐León, Yu‐Hsuan Huang, Victoria French, Guanggan Hu, Jen Chin C. Wang, Matthias Kretschmer, Xianya Qu, Raphaell Moreira, Earl Johan Foster, Pauline Johnson, James W. Kronstad

This study shows that polyphosphate mobilization is critical for Cryptococcus neoformans virulence in a mouse model, affecting cell surface structure, immune response, and mitochondrial function.

Infection and Immunity · Mar 12, 2025Peer-reviewedMicrobiology