AGC kinase homology requires and enables co-targeting for CNS regeneration
Hassan Al‐Ali, Abdiel Badillo-Martinez, Bassel Awada, Brian Silver, Omar S. Elwardany, Ronald Buckle, Graham Johnson, Siyuan Sun, Rodrig Rodrig Lendof, Nikhita Guha, Praveen Singh, Jae K. Lee, John L. Bixby, Vance Lemmon
The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.
bioRxiv · Sep 7, 2026 · PreprintNeuroscience