Mina Gouti

This study develops a scalable neuromuscular organoid platform to analyze drug responses in spinal muscular atrophy, showing distinct muscle and neuronal responses to SMN2 splicing modulators.

This study uses electrical stimulation to enhance the maturation of human neuromuscular organoids, improving their structural and functional properties.

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

The paper challenges the established model of neural induction by showing that cells commit to anterior or posterior regional identities before acquiring neural identity.

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.