Raquel Romero-Bueno

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

This paper introduces a C. elegans model of progeria by mutating baf-1 to mimic the human NGPS mutation, showing accelerated aging and altered gene expression.

The paper expands the FLP toolkit in C. elegans by adding new driver lines and a protein degradation system, enabling precise gene inactivation and transcriptomic profiling.