Christian G. Riedel

Pasta, a versatile transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenation

Pasta is a transcriptomic aging clock that predicts biological age across tissues and data types, identifies age-modulatory compounds, and links aging to mitochondrial translation and mRNA splicing.

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

This paper introduces a C. elegans model of progeria by mutating baf-1 to mimic the human NGPS mutation, showing accelerated aging and altered gene expression.

Cactus: a user-friendly and reproducible ATAC-Seq and mRNA-Seq analysis pipeline for data preprocessing, differential analysis, and enrichment analysis

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans

This study identifies SET-26 and HCF-1 as factors that antagonize HDA-1 to regulate gene expression and longevity in C. elegans.

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

The paper investigates how primary cilia influence human neuron differentiation via the WNT signaling pathway, identifying a critical 'ciliary time window' for axon development.

SIN3 acts in distinct complexes to regulate the germline transcriptional program in C. elegans

This study identifies two distinct SIN3 complexes in C. elegans that regulate germline gene expression and fertility, revealing their role in X-linked gene silencing.