Javier Vargas

This study identifies structural constraints in rotavirus spike protein loops that regulate proteolytic activation necessary for infectivity.

The paper identifies a limitation in existing cryo-EM map anisotropy measurement methods and shows that post-processing can reduce anisotropy.

DeepEMhancer improves cryo-EM map quality using deep learning, achieving cleaner and more detailed maps on test cases like SARS-CoV-2 RNA polymerase.

This study uses cryo-electron microscopy to determine the structure of the inactive conformation of the 30S ribosomal subunit and analyze its motions and structural changes under different conditions.

This study investigates Era's role in 30S ribosomal subunit assembly using mass spectrometry, cryo-EM, and in-cell footprinting, showing that most rRNA domains can fold without Era and that Era binding affects the decoding center.

This work introduces a soft-alignment validation method to assess alignment precision, accuracy, and data homogeneity in cryo-EM single particle analysis, improving map resolution through data quality enhancement.