Laura K. Hamilton

The paper develops a CRISPR/Cas9 electroporation and single-cell cloning protocol for human myoblasts, achieving high editing success rates and purity.

This study uses single-cell sequencing to analyze peripheral immune cell changes in Parkinson's disease patients, identifying key immune signatures and potential biomarkers.

This study shows that two ketogenic diets improve cognition and metabolic health in Alzheimer's disease mouse models, with distinct effects on peripheral metabolism.

The paper introduces a multiplexing strategy for scRNA-seq of adult mouse brain samples using anti-Thy1.2 antibodies and secondary oligonucleotide-labeled antibodies, enabling pooled sequencing with efficient demultiplexing and cost reduction.

This study shows that inhibiting Stearoyl-CoA Desaturase in the brain of 3xTg-AD mice improves cognitive function without affecting peripheral metabolic symptoms.