Sara R. Guerreiro

This study examines HPA-axis regulation and corticosterone fluctuations in SCA3 mice, finding normal HPA-axis function and minimal stress impact on disease progression.

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

This study tests the 5-HT1A agonist NLX-112 in SCA3 mice, finding it improves motor performance in a swimming test.

This study evaluates NLX-112, a 5-HT1A receptor agonist, in a mouse model of SCA3, showing improved motor function and neuroprotection when administered pre-symptomatically.