Sara Duarte‐Silva

This study examines HPA-axis regulation and corticosterone fluctuations in SCA3 mice, finding normal HPA-axis function and minimal stress impact on disease progression.

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

This study tests the 5-HT1A agonist NLX-112 in SCA3 mice, finding it improves motor performance in a swimming test.

This study evaluates NLX-112, a 5-HT1A receptor agonist, in a mouse model of SCA3, showing improved motor function and neuroprotection when administered pre-symptomatically.

This study identifies ATXN3's role in regulating neuronal mRNA splicing and Tau isoform ratio through deubiquitylation of splicing factors, linking it to SCA3 pathology.

This study shows that in a mouse model of SCA3, abnormal cerebellar output occurs early, before visible neuronal damage, and may be a target for therapy.

MorphData automates the extraction of morphological features from microglial cells in ImageJ, reducing data collection time from weeks to minutes.