Author

Alexandra Silva

Universidade do PortoORCID 0000-0001-7604-792XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Andreia Teixeira‐CastroiD· 2 shared Daniela Vilasboas‐CamposiD· 2 shared Francisco FigueiredoiD· 2 shared Patrı́cia MacieliD· 2 shared Pedro Miguel MartinsiD· 2 shared Sandra Macedo‐RibeiroiD· 2 shared Ana Luı́sa CarvalhoiD· 1 shared Andreia Neves‐CarvalhoiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

Andreia Teixeira‐CastroORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies

Alexandra Silva, Sara Duarte‐Silva, Pedro Miguel Martins, Beatriz Rocha Ilidio Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Pérez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana S. Fraga, James W. Noble, Carter Lantz, , Sandra Macedo‐Ribeiro

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

Advanced Science · Nov 26, 2025Peer-reviewedBiophysics

Drug repurposing of dopaminergic drugs to inhibit Ataxin-3 aggregation

Francisco Figueiredo, Zsuzsa Sárkány, Alexandra Silva, Daniela Vilasboas‐Campos, Patrı́cia Maciel, Andreia Teixeira‐Castro, Pedro Miguel Martins, Sandra Macedo‐Ribeiro

This study identifies dopamine and catecholamines as inhibitors of Atx3 aggregation, suggesting potential use of dopaminergic drugs for MJD treatment.

Biomedicine & Pharmacotherapy · Aug 5, 2023Peer-reviewedNeuroscience

Molecular tools for phytoplankton monitoring samples

Bárbara Frazão, Alexandra Silva

This paper evaluates DNA extraction methods and polymerases for phytoplankton monitoring, finding that Direct PCR master mix is the most effective for routine use.

bioRxiv · Jun 7, 2018 · PreprintMolecular Biology